Members of the UC San Diego Moores Cancer Center have developed strong, thriving, well-funded programs of research.
Cancer Biology and Signaling
Cancer Biology and Signaling is focused on fundamental mechanisms in two general areas of biology: signal transduction and developmental biology. Acknowledging the complexity of the signal transduction network that governs the basic processes of cell proliferation, differentiation and cell death, members of Cancer Biology also develop tools for high-throughput and computational analyses of the regulatory network.
Structural and Functional Genomics
Structural and Functional Genomics focuses on classical and molecular genetics and systems biology approaches in the study of cancer, both for understanding the genetic basis of the disease and to identify targets for therapeutic intervention. With the increasing availability of genome sequences and powerful new genetic technologies, the time may never be better to obtain genetic insights into the development of cancer.
Cancer Control is focused on improving the current knowledge base to promote overall reductions in cancer incidence, mortality and morbidity as outlined by the 2010 Health Goals for the nation. Studies include: 1) promoting the decline in tobacco consumption in the United States; 2) improving lifestyle patterns observed to be protective against cancer; 3) studying the efficacy of cancer prevention efforts; and 4) improving exposure measures used in cancer prevention and control studies.
Hematologic Malignancies seeks to improve our understanding of molecular characteristics and treatment of leukemias and lymphomas. Examining the differences between cancer and normal cells has provided insight into the molecular and biochemical features that define the malignant phenotype. Ultimate understanding of these mechanisms will help investigators to identify molecular pathways or antigens that are receptive to drugs and/or immune therapy.
Solid Tumor Therapeutics
The primary interest of members in Solid Tumor Therapeutics is to develop novel therapeutics and diagnostic tools based on insights into the basic mechanisms that control the growth and drug sensitivity of tumors, how they interact and invade into adjacent tissues, and how they metastasize to distant sites.