Pilot Grant Awardees

​​​​​​​​​​​​​​​Padres Pedal the Cause Grants: C3 / Rady Children's Hospital

2018

Spring 2018 

$125K/year 

C3 Project 1

“Natural Killer Cells for Treatment of Medulloblastoma” 
Dan Kaufman, MD, PhD (Moores Cancer Center)​ 
Robert Wechsler-Reya, PhD (Sanford Burnham) 
Abstract

C3 Project 2
“Understanding and Targeting NRF2 in Pancreatic Cancer” 
Michael Karin, PhD (Moores Cancer Center) 
Andrew Lowy, MD (Moores Cancer Center)
Jorge Moscat, PhD (Sanford Burnham)
Abstract

C3 Project 3

“Targeting a Therapeutic Vulnerability in PTEN-Deficient Brain Tumors”
Frank Furnari, PhD (Moores Cancer Center)
Geoff Wahl, PhD (Salk Institute for Biological Studies)
Abstract

C3 Project 4

“Enhanced Breast Cancer Risk Prediction from Imputed Gene Expression”
Hannah Carter, PhD (Moores Cancer Center)
Graham McVicker, PhD (Salk Institute for Biological Studies)
Abstract

C3 Project 5

"Inducing cytosolic chromatin fragments in cancer cells to turn cold tumors hot"
Jack Bui, MD, PhD (Moores Cancer Center)
Peter Adams, PhD (Sanford Burnham)
Abstract

C3 Project 6

“Epigenetic Profiling of Endometrial Cancer”
Diana Hargreaves, PhD (Salk Institute for Biological Studies)
Ramez Eskander, MD (Moores Cancer Center)
Abstract

C3 Project 7
"Targeting fibroblast heterogeneity to improve surgical outcomes in pancreatic cancer"
Ronald M. Evans, PhD (Salk) 
Michael Bouvet (Moores Cancer Center)
Abstract

$100K/year 

C3 Project 8
"Responses of Melanoma Patients to Checkpoint Immunotherapy"
Linda Bradley, PhD (Sanford Burnham)
Greg Daniels, MD, PhD (Moores Cancer Center)
Abstract

C3 Project 9

“Development and Implementation of a Peer-Navigation Intervention to Improve Research Literacy in Pediatric Cancer Trials”
Paula Aristizabal, MD (Rady Children’s Hospital)
Elena Martinez, PhD (Moores Cancer Center) 
Abstract

C3 Project 10

“A Novel Role for Histidine Kinase Activity in Neuroblastoma Pathogenesis”
Peter Zage, MD, PhD (Rady Children’s Hospital)
Tony Hunter, PhD (Salk Institute for Biological Studies)
Abstract

Fall 2018 

C3 Project 1
"Low Dose Chemotherapy for Immuno-activation in Lung Cancer"
Hatim Husain, MD (Moores Cancer Center)
Michael Karin, PhD (Moores Cancer Center)
Abstract

C3 Project 2
"Investigating the Efficacy of radium-223 with Olaparib in Men with Metastatic Castration-resistant Prostate Cancer"
Rana R. McKay, PhD (Moores Cancer Center)
Christina Jamieson, PhD (Moores Cancer Center)
Abstract

C3 Project 3
"A Phase 1b pilot clinical trial of cirmtuzumab, an anti-ROR1 monoclonal antibody, in combination with paclitaxel for the treatment of patients with metastatic, or locally advanced, unresectable breast cancer"
Barbara A. Parker, MD (Moores Cancer Center)
Rebecca A. Shatsky, MD (Moores Cancer Center)
Abstract

C3 Project 4
"An Open-Label, Phase 2 Efficacy Study of Temozolomide (TMZ) In Advanced Succinate Dehydrogenase (SDH)-Mutant/Deficient Gastrointestinal Stromal Tumor (GIST)"
Jason Sicklick, MD (Moores Cancer Center)
Adam Burgoyne, MD, PhD (Moores Cancer Center)
Abstract

C3 Project 5
"A Phase 1b Safety and Feasibility Study of Personalized Immunotherapy in Adults with Advanced Cancers"
Ezra Cohen, MD (Moores Cancer Center)
Stephen Schoenberger, PhD (La Jolla Institute)
Aaron Miller, MD, PhD (Moores Cancer Center)
Abstract

C3 Project 6
"Targeting FZD7 in human cancers"
Karl Willert, PhD (Moores Cancer Center)
Dennis Carson, MD (Moores Cancer Center)
Abstract

$125K/year 

C3 Project 7
"Inhibiting Liver Cancer Stem Cells to Improve Response to Thermal Ablation"
Isabel Newton, MD (Moores Cancer Center)
Nicholas Webster, PhD, MA (Moores Cancer Center)
Gen-Sheng Feng, PhD  (Moores Cancer Center)
Abstract

C3 Project 8
"Targeting CD114 Signaling in Pediatric Medulloblastoma"
Peter Zage, MD, PhD (Rady Children's Hospital)
Robert Wechsler-Reya, PhD (Sanford Burnham Prebys)
Pablo Tamayo, PhD (Moores Cancer Center)
Abstract

C3 Project 9
"Evaluation of carcinogen exposure via genome-wide DNA-adduct signatures"
Olivier Harismendy, MD, PhD (Moores Cancer Center)
Ludmil Alexandrov, PhD (Moores Cancer Center)
Jason Sicklick, MD (Moores Cancer Center)
Abstract

C3 Project 10
"Impact of Metformin on Clonal Hematopoiesis and Clinical Outcomes in Breast Cancer"
Rafael Bejar, MD, PhD (Moores Cancer Center)
Dorothy Sears, PhD (Moores Cancer Center)
Abstract

$71K/year
C3 Project 11
"Knowledge-based planning and treatment decision-making for gynecologic brachytherapy"
Sandra Meyers, MD (Moores Cancer Center)
Kevin Moore, MD (Moores Cancer Center)
Jyoti Mayadev, MD (Moores Cancer Center)
Abstract

$50K/year

C3 Project 12
"Plant VLP in situ vaccination for treatment of glioma"
Nicole F. Steinmetz, Ph.D.
Jeremy N. Rich, MD, MHS, MBA
Abstract

2017

$75K/year 

C3 Project 1
“Irreversible Electroporation as an in situ Vaccine for Pancreatic Cancer”
Rebekah White, MD (Moores Cancer Center)​
Stephen Schoenberger, PhD (La Jolla Institute)
Aaron Miller, MD, PhD (Moores Cancer Center)
Abstract

C3 Project 2
“Oncogenic Regulation of B-Lymphomagenesis by the Chromatin Modulator DOT1L”
Bing Ren, PhD (Moores Cancer Center)
Anniruddha Deshpande, PhD (Sanford Burnham Prebys Cancer Center)

C3 Project 3
“An Over-expressed GPCR in Pancreatic Cancer-associated Fibroblasts as a Novel Therapeutic Target”
Paul Insel, MD (Moores Cancer Center)
Kristiina Vuori, MD, PhD (Sanford Burham Prebys Cancer Center)
Abstract

C3 Project 4
“Targeting Cellular Mechanotransduction in Breast Cancer Metastasis”
Jing Yang, PhD (Moores Cancer Center)
Elena Pasquale, PhD (Sanford Burnham Prebys Cancer Center)

C3 Project 5
“Identification of Genes Critical for the Production of T cells from Human Pluripotent Stem Cells for Development of "Off-the-Shelf" T cell Immunotherapies”
Dan Kaufman, MD, PhD (Moores Cancer Center)
Sumit Chanda, PhD (Sanford Burnham Prebys Cancer Center)
Abstract

C3 Project 6
“Decoding Colon Cancers Using Boolean Principles”
Pradipta Ghosh, MD (Moores Cancer Center)
Debashis Sahoo, PhD (Moores Cancer Center)
Manuel Perucho, PhD (Sanford Burnham Prebys Cancer Center)
________________________________________________________

$50K/year 

Rady Project 1
“Tissue-specific Role of SMARCB1 in Pediatric Rhabdoid Tumors”
Frank Furnari, PhD (Ludwig Institute for Cancer Research)​
John Crawford, MD (Rady Children's Hospital)
Abstract

Rady Project 2
“Deciphering the Rold of RNA Editing in Leukemia Stem Cell Generation and Pediatric Acute Leukemia Relapse”
A. Preethi Ganesan, MD, PhD (Rady Children's Hospital)
Catriona Jamieson, MD, PhD (Moores Cancer Center)

Rady Project 3
“Discovery of Non-coding Oncogenic Mutations in Pediatric Acute Lymphoblastic Leukemia Using ATAC-seq and Hi-C”
Graham McVicker, PhD (Salk Cancer Center)
Jesse Dixon, PhD (Salk Cancer Center)
Dennis Kuo, MD (Rady Children's Hospital)

Rady Project 4
“Identification of Therapeutic Targets of B-ALL Using Boolian Logic”
Debashis Sahoo, PhD (Moores Cancer Center)
Deborah Schiff, MD (Rady Children's Hospital)
Abstract

Rady Project 5
“Developing Targeted Therapy for Ewing Sarcoma Metastasis”
Jing Yang, PhD (Moores Cancer Center)
Sun Choo, MD (Rady Children's Hospital)
Abstract

Rady Project 6
“Novel Kinase Inhibitors in Combination with Retinoic Acid for Neuoblastoma”
Peter Zage, MD, PhD (Rady Children's Hospital)
Abstract

2016

$75K/year 

Project 1
“Targeting KRAS Mutant lung cancer with biphosphonated/statins and rapamycin analogs”
Lyudmila Bazhenova, MD (Moores Cancer Center)​
Inder Verma, PhD (Salk Institute Cancer Center)
Abstract

Project 2
“The GNAS-PKA Onco-Signaling Network in Colorectal Malignancies”
Silvio Gutkind, PhD (Moores Cancer Center)
Susan Taylor, PhD (Moores Cancer Center)
Tony Hunter, PhD (Salk Institute Cancer Center)

Project 3
“Epigenetic Basis of Platinum Drug-resistance in Ovarian Cancer”
Olivier Harismendy, PhD (Moores Cancer Center)
Stephen Howell, MD (Moores Cancer Center)
Joseph Ecker, PhD (Salk Institute Cancer Center)

Project 4
“KRAS Addiction and Protein Biomarkers of Response to Anti-KRAS Therapy in NSCLC Patient-derived Xenografts”
Hatim Husain, MD (Moores Cancer Center)
Garth Powis, DPhil (Sanford Burnham Prebys Cancer Center)

Project 5
“Mechanisms Linking Prolonged Nightly Fasting with Cancer Risk”
Ruth Patterson, PhD (Moores Cancer Center)
Dorothy Sears, PhD (Moores Cancer Center)
Satchidananda Panda, PhD (Salk Institute Cancer Center)

Project 6
“Targeting Stem Cell Signals in Cancer Development & Progression”
Tannishtha Reya, PhD (Moores Cancer Center)
Michael Jackson, PhD (Sanford Burnham Prebys Cancer Center)

Project 7
“Detecting Correlates of Vaccine Responses in Allogeneic Hematopoietic Stem Cell Transplant Recipients”
Randy Taplitz, PhD (Moores Cancer Center)
Shane Crotty, PhD (La Jolla Institute)​

2015

$75K/year 

Project 1
“Highly selective, synthetic, cleavage specificity-based nanobiosensors for tumorigenic and anti-tumorigenic MMPs”
Alex Strongin, PhD (Sanford Burnham Prebys Cancer Center)
Shu Chien, MD, PhD (Moores Cancer Center)
Peter Yingxiao Wang, PhD (Moores Cancer Center)
Abstract

Project 2
“Cytotoxic breast cancer treatment effects on aging”
Deborah Kado, MD, MS (Moores Cancer Center)
Jan Karlseder, PhD (Salk Cancer Center)
Abstract

Project 3
“In vivo modeling of anti-tumor responses of human melanoma patients and their responses to checkpoint immunotherapy”
Linda Bradley, PhD (Sanford Burnham Prebys Cancer Center)
Greg Daniels, MD, PhD (Moores Cancer Center)
Abstract

$300K/2 years 

Team Science Award
“Therapeutic reprogramming of pancreatic cancer stroma via modulation of p62 and p53”
Andrew Lowy, MD (Moores Cancer Center)
Geoffrey M. Wahl, PhD (Salk Cancer Center)
Cosimo Commisso, PhD (Sanford Burnham Prebys Cancer Center)
Jorge Moscat, PhD (Sanford Burnham Prebys Cancer Center)
Abstract

2014

$75K/year

Project 1
“Small molecule screen for inhibitors of the GOLPH3 pathway”
Seth Field, MD, PhD (Moores Cancer Center)
Michael Jackson, PhD (Sanford Burnham Prebys Cancer Center)
Abstract 

Project 2
“Applying p38 MAPK inhibitors to tackle breast cancer metastasis”
Michael Karin, PhD (Moores Cancer Center)
Geoffrey M. Wahl, PhD (Salk Cancer Center) 
Abstract

Project 3
“Stromal reprogramming to enhance the effectiveness of pancreatic cancer therapy”
Andrew Lowy, MD (Moores Cancer Center)
Geoffrey M. Wahl, PhD (Salk Cancer Center) 
Abstract

Project 4
“Targeting imatinib-resistant, KIT-negative cells in human GISTs”
Jason K. Sicklick, MD (Moores Cancer Center)
Robert J. Wechsler-Reya, PhD (Sanford Burnham Prebys Cancer Center)
Abstract 

Project 5
“Demonstrating the clinical utility of whole exome sequencing for cancer patients”
Lisa Madlensky, PhD (Moores Cancer Center)
Geoffrey M. Wahl, PhD (Salk Cancer Center)
Abstract

American Cancer Society - Institutional Research Grants (ACS-IRG)

2018

$30K/year 

"Determination of Cancer Persister Cell Mutational Rate"
Matthew Hangauer, PhD
Abstract

"Clinical Strategizing of PARP Inhibitors in Prostate Cancer"
Rana McKay, MD
Abstract

"Enhanced T-cell Regeneration Using Cell Instructive Scaffolds"
Nisargh Shah, PhD
Abstract

"Exploration of LMPTP as a New Target for Prostate Cancer Therapy"
Stephanie Stanford, PhD
Abstract

"Single Cell Transcriptomics and Epigenomic Profiling to Reveal Immune Landscape in Pediatric Sarcomas"
Anusha Ganesan, MD, PhD
Abstract

"Tumor Board Education Series Devising a Package for Dissemination and Implentation of Evidence Based Recommendations for the Staging and Treatment of Gastric Cancer with Stakeholder Input"
Kaitlin Kelly, MD
Abstract

2016

$30K/year

"A Chemistry-based Method for the Discovery of Irreversible Inhibitors with Anticancer Activity"
Chambers Hughes, PhD
Abstract

"T Lymphocyte Repertoire Determinants of Cancer Immunotherapy Response"
Gerald Morris, MD, PhD
Abstract

"Translational Control of Acute Myeloid Leukemia Stem Cells"
Robert Signer, PhD
Abstract

"Reducing Tumor Resection Margins Via Natural Medical Image Overlays through Wireless Augmented Reality Headsets"
Michael Yip, PhD
Abstract

"Su Voz: Advanced Care Planning Preferences Amoung Spanish-speaking Cancer Patients and their Caregivers (special interest award)"
Veronica Cardenas, PhD
Abstract

2015

$30K/year

"Photoacoustic Molecular Imaging of Ovarian Cancer"
Jesse Jokerst, PhD
Abstract

"Global Profiling of Extracellular Protease Activity from Lung Cancer Cells"
Anthony O'Donoghue, PhD
Abstract

"Restriction Spectrum Imaging for Presurgical Assessment of Neoadjuvant Treatment Response in Rectal Cancer"
Daniel Simpson, MD
Abstract

"The Role of Differential mRNA Localization in the Stress Adaption of Cancer Cells"
Brian Zid, PhD
Abstract

"Factors affecting Parental Satisfaction, Anxiety and Comprehension of Informed Consent in Pedatric Oncology Clinical Trials"
Paula Aristizabal, MD, MAS
Abstract

2014

$30K/year 

“Factors affecting parental satisfaction, anxiety and comprehension of the informed consent in pediatric oncology clinical trial” 
Paula Aristizabal, MD
Abstract

“Integrin αvβ3 drives an EMT-independent role for slug in cancer stemness” 
Jay Desgrosellier, PhD
Abstract

“Prospective metabolite biomarkers of human breast cancer” 
Mohit Jain, MD, PhD
Abstract 

“The role of misregulated epigenetic mechanisms in cellular transformation and colorectal carcinoma”
Shannon Lauberth, PhD
Abstract

“The cost-effectiveness of using nicotine replacement therapy and financial incentives to promote utilization of smokers’ quitlines and smoking cessation among Asian-language speakers: a randomized, controlled pilot trial” 
Yuyan Shi, PhD
Abstract

“Utilizing FRET biosensors to optimize the targeting efficacy of CAR-based T-cell immunotherapy for individual B-ALL patients”
Xiandong Xu, MD, PhD
Abstract

2013

$30K/year 

“Translational bioinformatics of the NCI 60 proteome” 
Nuno Bandeira, PhD
Abstract

“Ultra-sensitive protein detection for early cancer diagnostics using magnetic tunnel junction (MTJ) biosensors” 
Drew Hall, PhD
Abstract

“Quantitative neuroimaging and neurocognitive assessment to measure radiation-induced brain injury in non-targeted tissue: implications for cognitive preservation” 
Jona Hattangadi-Gluth, MD
Abstract

“The role of misregulated epigenetic mechanisms in cellular transformation and colorectal carcinoma” 
Shannon Lauberth, PhD
Abstract

“Counterfeit Avastin health policy and legal analysis to improve cancer patient safety and public health”
Timothy Mackey, PhD
Abstract

Cancer Center Support Grant (CCSG)

2018​

$50K/year

“Therapeutic Targeting of Brain Tumors as Informed by Oncogenic Gene-Enhancer Network Inference”
Lukas Chavez, PhD and John Crawford, MD
Abstract

“DRRK2: A novel Therapeutic Target for Multiple Myeloma”
Jack Dixon, PhD and Caitlin Costello, MD
Abstract 

“Rapid Isolation of Circulating Exosomes for Early Detection of Pancreatic Cancer”
Rebekah White, MD and Karen Messer, PhD 
Abstract

201​7

$50K/year 

“Targeting Cancer Stem Cell Signaling as a Strategy against Platinum-resistant Ovarian Cancer” 
David Schlaepfer, PhD and Michael McHale, MD
Abstract

“Immune Biomarkers of Response to BTK Inhibitors in HNSCC Patients” 
Judith Varner, PhD and Kate Gold, MD
Abstract

“Molecular Profiling of Circulating Tumor Cells to Predict Responses to Chemotherapy in Breast Cancer Patients” 
Jing Yang, PhD and Barbara Parker, MD
Abstract

2017 Breath of Hope Pilot Grant

“Engineering Lung Cancer Cells into Immune Stimulatory Dendritic Cells” 
Jack Bui, MD, PhD and Sandip Patel, MD 
Abstract

201​6

$50K/year 

“Harnessing the full potential of novel immune therapies for oral cancer prevention and treatment” 
Silvio Gutkind, PhD and Ezra Cohen, MD
Abstract

“Therapeutic and Prognostic Potential of a Novel Signaling Pathway in Colorectal Cancer” 
Pradipta Ghosh, MD and Samuel Ho, MD
Abstract

“IND enabling studies of LT-415 a novel chemotherapeutic agent with a unique target” 
William Fenical, PhD and Stephen Howell, MD
Abstract​

2016 Breath of Hope Pilot Grant

“Monitoring the Dynamics of Early Tumor Response to Therapy by Detecting Circulating Tumor DNA in Blood and Urine” 
Hatim Husain, MD
Abstract​

2014

$50K/year 

“Copper PET imaging as a biomarker for prediction of response to cisplatin” 
Stephen Howell, MD, and David Vera, PhD
Abstract

“Imaging the metastatic potential of single tumor cells in lung adenocarcinoma” 
Pradipta Ghosh, MD, and Hatim Husain, MD
Abstract

“Prospective evaluation of restriction spectrum imaging in head and neck carcinoma” 
Quyen Nguyen, MD, PhD, and Anders Dale, PhD
Abstract

“Restriction spectrum imaging as a biomarker for monitoring disease progression and early response to therapy in patients with high-grade glioma” 
Carrie McDonald, PhD, and Jona Hattangadi-Gluth, MD
Abstract

“Development of theranostic antibody targeted delivery of radio sensitizers”
 Sunil Advani, MD, and Roger Tsien, PhD 
Abstract

Cancer Imaging Grants

2015

$20K/year 

“Abbreviated MRI vs. standard ultrasonography for hepatocellular carcinoma Surveillance in cirrhosis.” 
Claude Sirlin, MD, and Yuko Kono, MD, PhD
Abstract

“An integrative approach to histological sections – accelerating the integration of multi-modality imaging into clinical practice.” 
Hauke Bartsch, PhD, and David Hall, PhD
Abstract

“Preliminary evaluation of RSI MRI for whole body cancer detection.” 
David Karow, MD, PhD, J. Michael Randall, MD, and Joshua Kuperman, PhD
Abstract 

“Opto-acoustic imaging of a receptor-targeted contrast agent for detection of aggressive breast cancer.” 
David Vera, PhD, and Anne Wallace, MD
Abstract

“Enzyme-directed assembly of particle diagnostics for guided surgical resection of tumors.” 
Nathan Gianneschi, PhD, and Quyen Nguyen, MD, PhD
Abstract

“Radiation sparing of eloquent cortex in brain tumor patients using advanced quantitative neuroimaging and knowledge-based planning.”
Jona Hattangadi-Gluth, MD, and Kevin Moore, PhD
Abstract

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