UC Translational Medicine Leaders Celebrate Achievements with an Eye Toward the Future

UC BRAID Leaders

UC BRAID program leaders, from left, are Clay Johnston, MD, PhD (UCSF), Dan M. Cooper, MD (UC Irvine), Gary S. Firestein, MD (UC San Diego), Lars Berglund, MD, PhD (UC Davis), and Steven M. Dubinett, MD (UCLA), with Steven Beckwith, Vice President for Research and Graduate Studies at the University of California in the Office of the President. (Photo by Christina McCabe, UCSD)

UC BRAID Holds Annual Retreat in San Diego

October 23, 2013 - The path forward is clear: To continue and enhance the development of a robust coordinating center that combines the individual University of California (UC) health campuses into a model virtual biomedical research institution.

That's the conclusion reached by representatives of the University of California Biomedical Research Acceleration, Integration, and Development (UC BRAID) program during an annual retreat held at UC San Diego on October 15. About 70 translational medicine researchers, administrative leaders, staff and faculty representing seven UC campuses met to discuss next steps along the path, identify potential research intersections and share the achievements for UC BRAID.

"The largest role for BRAID is enabling partnerships, and that will help us reach our goal of reducing barriers to biomedical research," said Gary S. Firestein, MD, UC BRAID chair, director of UC San Diego's Clinical and Translational Research Institute and dean and associate vice chancellor of translational medicine at UC San Diego.

Established in 2010, UC BRAID, in collaboration with the University of California Office of the President (UCOP), is a joint effort of the five UC biomedical campuses to catalyze, accelerate, and reduce the barriers for biomedical, clinical, and translational research across the UC system. The UC BRAID consortium — UC's Davis, Irvine, Los Angeles, San Diego, and San Francisco — pools data, resources and expertise to reach this goal. UC Riverside and Santa Cruz also participated in this year's UC BRAID meeting.

Major successes of UC BRAID highlighted at the 2013 retreat were:

  • UC-Research eXchange consortium (UC-ReX): UC BRAID launched the consortium's first tool from UC ReX, namely the Data Explorer, building the first cross-campus clinical query system capable of exchanging patient-level data, as well as aggregates (counts and descriptive statistics). The UC ReX Data Explorer enables search of 12 million de-identified patient records from the five UC medical centers with one query.
  • U54 Center for Accelerated Innovation (CAI): NIH's National Heart, Lung and Blood Institute awarded $12 million to UC to create a Center for Accelerated Innovation (CAI). UC BRAID oversees this new center aimed at translating innovations into improved health.

"An important part of UC BRAID's mission is to improve UC collaborative research opportunities. UC ReX is a great example of how UC BRAID accomplishes this," said Firestein, who went on to laud the CAI as a UC BRAID accomplishment. "The new U54 CAI is a remarkable example of inter-institutional collaboration." Michael Palazzolo, MD, a Professor of Medicine at UCLA, is the principal investigator for CAI.

Dr. Firestein and UC Braid Director Rachael Sak, RN, MPH, gave presentations about how UC BRAID takes research from silos to collaboration and how to leverage the program. Firestein cited examples of silos in academic medicine as multiple cores performing the same service, different IT systems in clinical research, and resistance to central institutional review boards.

He emphasized the urgency of change, building a guiding team and getting the vision right. "We must empower change, remove obstacles, and reward progress," the UC BRAID chair said.

Clay Johnston, MD, a member of the UC BRAID Executive Committee, added that UC BRAID realizes its vision by identifying areas of collaboration, aligning across multi-campus initiatives, and evaluating priorities and making funding recommendations. "We were established to identify and address, on a system-wide level, the shared challenges of academic translational science," Johnston said.

Other key topics at the retreat included biorepositories, contracting, regulatory, and drug and device discovery and development. Participants also discussed the new BRAID Child Health Initiative to expand research for the pediatric population.

Written by Patti Wieser


About UC San Diego Altman Clinical and Translational Research Institute:

UC San Diego Altman Clinical and Translational Research Institute (ACTRI) is part of a national Clinical and Translational Science Award consortium, led by the National Institutes of Health National Center for Advancing Translational Science. Established in 2010, ACTRI provides infrastructure and support for basic, translational and clinical research throughout the San Diego region to bring discoveries from the laboratory to the bedside, and facilitates training and education of the next generation of researchers. ACTRI carries out its activities in collaboration with institutional and corporate partners and currently has more than 1,500 members.

actri.ucsd.edu