Director's Message: Autumn 2012

Dr. Firestein

To promote novel and cross-disciplinary translational research, the CTRI supports access to specialized laboratory assays and technology. Often, sophisticated assays require specialized training and instrumentation that is prohibitively expensive for an individual laboratory to buy, maintain, and operate. This is particularly true if the need is short-term.

For example, the CTRI Translational Research Technologies (TRT) Division provides access to the resources of the Conrad Prebys Center for Chemical Genomics, the Department of Orthopedics Leica Digital Imaging Hub, the UCSD Genomics Core at the Sanford Consortium, and the Biomolecular and Proteomics Mass Spectrometry Facility.

The Conrad Prebys Center for Chemical Genomics, located at the Sanford Burnham Medical Research Institute, can provide assistance converting an investigator’s prototype assay into an automated, high-throughput system, and then uses that to screen millions of candidates in chemical libraries to identify potential new therapeutic agents. The Leica Digital Imaging Hub permits high-end brightfield and fluorescence digital scanning for pathology and other applications; images can be viewed using either the SlidePath Gateway client or SlidePath Gateway for iPad and iPhone. The Genomics Core is supported by the CTRI and is physically located at the Sanford Consortium for Regenerative Medicine. It provides medium-throughput genomics assays based on Fluidigm and Illumina platforms to measure genetic variation and gene expression. The Biomolecular and Proteomics Mass Spectrometry Facility carries out multidimensional chromatographic separations and quantitative proteomics, analysis of both proteins and peptides, sequencing, and characterization of posttranslational modifications, among other functions.

In addition to providing services and collaborations to translational investigators, the CTRI is pleased to offer funding opportunities for projects involving mass spectroscopy and high throughput drug screening. To access any TRT resources, including the ones mentioned above, visit the CTRI Service Request page or the Translational Research Technology (TRT) Division page.

Gary S Firestein, MD, Director of CTRI
Professor of Medicine Dean and Associate Vice Chancellor of Translational Medicine
Phone: (858) 822-3824