Clinical research is defined in accordance with the NIH definition as research conducted with human subjects or on material collected from humans for which an investigator directly interacts with a human subject to broaden knowledge about mechanisms of disease, therapeutic interventions, or clinical trials, or to develop new technology. Epidemiological population based, behavioral studies and community interventions, as well as outcomes and health services research, are considered clinical research.
Translational research defined to include four emphases:
- T1: translational research includes the process of applying basic research discoveries to develop trials and other studies in humans (i.e., case series, phase I and II clinical trials).
- T2: translational research is directed at better patient outcomes and the development of evidence based guidelines.
- T3: translational research implements evidence‐based guidelines into health practice through community practice (delivery, dissemination, and diffusion research).
- T4: translational research evaluates the health outcomes of applications of translational research in the community.
Innovative technology research is defined as pojects that develop new technology to assess disease susceptibility, pathogenesis, or severity that could potentially be applicable to clinical research. Funding is not intended to support adaptation or modification of existing technology, such as flow cytometry, qPCR, ELISAs, etc. A particular focus on biomarker or imaging modalities is anticipated, such as novel proteomics techniques or developing novel imaging agents. Proposal must include a clinical researcher to serve as co-investigator to assure disease relevance.