The National Heart, Lung and Blood Institute (NHLBI) created the Programs of Excellence in Glycosciences (PEG) in 2011 to translate emerging discoveries into new diagnostics and clinical applications, to build research capacity including technological resources, and a cadre of "scientifically bilingual" investigators fluent in glycan chemistry and biology that will sustain and advance the application of glycosciences to heart, lung, and blood research.
National Administrative Center
UC San Diego was selected as the National Administrative Center (PEGNAC) by the NHLBI, and served as the coordinator of the six Programs of Excellence in Glycosciences' across the nation. The Center performed a range of functions including organizing investigator meetings, conference calls, and External Review Panel meetings.
UCSD PEG Program
In 2011 the NHLBI recognized a group of GRTC investigators at UC San Diego as one of the six PEG programs. This multidisciplinary partnership brought experts and new investigators together to focus on glycans and glycan-binding proteins in innate immunity, revealing many important functions in health and disease.
Our program consisted of four innovative glycoscience research projects and five state-of-the-art core facilities.
UC San Diego PEG Projects
- Siglec Modulation of Inflammatory Responses PI: Ajit Varki
- Microbial Glycan Mimicry and Glycosides in Inflamatory Responses PI: Victor Nizet
- Genetic Analysis fo Glycosaminoglycans in Inflammatory Responses PI: Jeffrey D. Esko
- Hyaluronan Catabolism in Inflammatory Responses PI: Richard Gallo
UC San Diego PEG Research Cores
- Glycosciences Skills Development Director: Jeffrey D. Esko
- Shared Resources Core: Glycan Analysis & Synthesis Director: Biswa Choudhury, Co-I: Geert-Jan Boons
- Administrative and Mouse Management Director: Ajit Varki
- Histopathology Director: Nissi Varki
- Hematology and Clinical Chemistry Director: Dzung Le