Current Literature in Glycobiology (Journal Club)

MED 246 / BIOM 246 / CMM 246   |  Fall, Winter, Spring Quarters  |  Fridays 12:00 - 1:00pm
Course Director:  Lars Bode
Co-Directors: Jeffrey D. Esko, Pascal Gagneux, Ajit Varki, Philip Gordts
Units: 1

2018 Orientation:  Friday September 28, 2018, 12:00 - 1:00pm
Biomedical Research Building II (BRF2) Room 4103

Current Literature in Glycobiology is a one-credit (per quarter) elective that provides a forum for informally discussing current papers in glycobiology research. Topics include glycan chemistry, biochemistry, genetics, cell biology, and molecular biology in animals, plants and microbes, as well as medical aspects of glycobiology.

​DATE	TOPIC	​SPEAKER
​September 28	​INTRODUCTION      Paper Guidelines.pdf Glycobiology Journal Club Intro Slides Harrison's Principles of Internal Medicine, 20e	​All Instructors
​October 5	​Rapid detection of Mycobacterium tuberculosis in sputum with a solvatochromic trehalose probe	​Ryan Weiss Esko Lab
​October 12	​Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships.pdf	​Mike Vaill Varki Lab
​October 19	​Ribitol restores functionally glycosylated α-dystroglycan and improves muscle function in dystrophic FKRP-mutant mice	​Chelsea Painter Esko Lab
​October 26	​HAase activity glucose metabolism.pdf	​Greg Golden Esko Lab
​November 2	​Loss of GCNT2 I-branched glycans enhances melanoma growth and survival.pdf Supplemental.pdf	​Phillip Bartels Tor Lab
​November 9	​J. Biol. Chem.-2018-Ndeh-jbc.RA118.004510.pdf	​Chirag Dhar Varki Lab
​November 16	​O-GlcNAcylation mediates metastasis of cholangiocarcinoma through FOXO3 and MAN1A1.pdf Supplemental Information.pdf	​Charlotte Spliid Esko Lab
​November 23	​THANKSGIVING HOLIDAY	​
​November 30	​Hyaluronidase inhibits reactive adipogenesis and inflammation of colon and skin.pdf	​Bastian Ramms Gordts lab
​December 7	​Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1 Supplemental Info.pdf	Hector Cuello Esko Lab
​December 14	Adipocyte OGT governs diet-induced hyperphagia and obesity Supplemental Information_Li	​Ariane Pessentheiner Gordts Lab
​December 21	​CHRISTMAS BREAK	​
​December 28	​CHRISTMAS BREAK	​
​January 4	​M6P Lysosomal Targeting Paper.pdf M6P paper Supplemental.pdf	​Ryan Porell Godula Lab
​January 11	​Accelerated Aging and Clearance of Host Anti-inflammatory Enzymes by Discrete Pathogens Fuels Sepsis	​Sun-Mi Choi Nizet Lab
​January 18	​N-linked glycosylation restricts the function of Short gastrulation to bind and shuttle BMPs	​Miguel Tillo Gordts Lab
​January 25	​Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans	​Sudeshna Saha Varki Lab
​February 1	​SDGS	​
​February 8	​Antibiotic sensitivity reveals that wall teichoic acids mediate DNA binding during competence in Bacillus subtilis.pdf Suuplemental Information.pdf	​Joanna Coker Zengler Lab
​February 15	​Improving vaccines against Streptococcus pneumoniae using synthetic glycans.pdf pnas.1811862115.sapp.pdf	​Wilson Lin Kadonaga Lab
​February 22	​O-GlcNAc modification of eIF4GI acts as a translational switch in heat shock response.pdf SUPP_oglcnac_mod_eif4gi_transl_switch_zhang-etal.pdf	Mark Fang Yeo Lab
​March 1	CLASS CANCELLED	​
​March 8	​Association of cytosolic sialidase.pdf	​Patricia Gnieslaw de Oliveira Guma Lab
​March 15	​Galectin-3 deficiency drives lupus-like disease by promoting spontaneous germinal centers formation via IFN-γ.pdf	​Naazneen Khan Varki Lab
​March 22	​Galectin binding to cells and glycoproteins with genetically modified glycosylation reveals galectin–glycan specificities in a natural context	​Friederike Jessen Gordts Lab
​March 29	​CESAR CHAVEZ HOLIDAY observed	​
​April 5	​α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson’s disease	​Patricia Aguilar-Calvo Sigurdson Lab
​April 12	​Core fucose is essential glycosylation for CD14-dependent Toll-like receptor 4 and Toll-like receptor 2 signalling in macrophages	​Raquel Riley Esko Lab
​April 19	​The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins	​Thomas Clausen Esko Lab
​April 26	​Adipose tissue loss and lipodystrophy in xylosyltransferase II deficient mice	​Markus Heine Gordts Lab
​May 3	​Circulating heparan sulfate fragments mediate septic cognitive dysfunction	​Saurabh Srivastava Varki Lab
​May 10	CLASS CANCELLED​	​
​May 17	​Glycoconjugate vaccine using a genetically modified O antigen induces protective antibodies to Francisella tularensis	​​So-Young Kim Fuster Lab
​May 24	​A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host	Yang Ji Varki Lab​