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Current Literature in Glycobiology / Glyco Journal Club

MED 246 / CMM 246 | Every Fall, Winter, Spring Quarter | Time: 12:00 - 1:00 pm
Day: Friday
First Day: Friday, January 12, 2024
Location: Biomedical Research Facility, Room 4103
Course Director: Philip Gordts
Co-Instructors: Jeffrey D. Esko, Pascal Gagneux, Ajit Varki, Kamil Godula, Amanda Lewis, Lars Bode
Course TAs: Nathan Thomas, Jill Hauer
Units: 1

Symbol Nomenclature for Glycans (SNFG):
https://www.ncbi.nlm.nih.gov/glycans/snfg.html

Harrison's Principles of Internal Medicine:
https://accessmedicine.mhmedical.com/book.aspx?bookid=3095

Current Literature in Glycobiology is a one-credit (per quarter) elective that provides a forum for informally discussing current papers in glycobiology research. Topics include glycan chemistry, biochemistry, genetics, cell biology, and molecular biology in animals, plants and microbes, as well as medical aspects of glycobiology.

DATE PAPER PRESENTER
9/29/23 Orientation & Paper Selection

Paper 1: Structural basis for heparan sulfate co-polymerase action by the EXT1-2 complex

Paper 2: Structure of the human heparan sulfate polymerase complex EXT1-EXT2

Prof. Philip Gordts, Nathan Thomas, Jill Hauer
10/6/23 Presenters select papers Nathan Thomas/Jill Hauer
10/13/23 Targeted glycan degradation potentiates cellular immunotherapy for solid tumor Chung-Jui (Raymond)
10/20/23 Increased 3-O-sulfated heparan sulfate in Alzheimer's disease brain is associated with genetic risk gene HS3ST1 Staci Barnes
10/27/23 Design of a mucin-selective protease for targeted degradation of cancer-associated mucins Reid Larsen
11/3/23 Spatial imaging of glycoRNA in single cells with ARPLA. Garland Jackson
11/10/23 NO CLASS - VETERANS DAY
11/17/23 Sydney Morrill
11/24/23 NO CLASS - THANKSGIVING HOLIDAY
12/1/23 O-glycan structures in apo(a) subunit of human lipoprotein(a) suppresses the pro-angiogenic activity of galectin-1 on human umbilical vein endothelial cells Julianna Follmar
12/8/23 Chondroitin 4- O-sulfation regulates hippocampal perineuronal nets and social memory Francesca Boscolo
1/12/24 Introduction / Paper Selection Nathan Thomas/Jill Hauer
1/19/24 ST6GAL1-mediated aberrant sialylation promotes prostate cancer progression Sarah Wax
1/26/24 Inducible CRISPR-targeted “knockdown” of human gut Bacteroides in gnotobiotic mice discloses glycan utilization strategies Savanna Pflugmacher
2/2/24 Metabolic glycan labeling immobilizes dendritic cell membrane and enhances antitumor efficacy of dendritic cell vaccine Hyesoo Kim
2/9/24 Disruption of sugar nucleotide clearance is a therapeutic vulnerability of cancer cells Nathan Le
2/16/24 Glycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE Tricia Lenhart-Pendergrass
2/23/24 Glycoengineered keratinocyte library reveals essential functions of specific glycans for all stages of HSV-1 infection Cameron Pormir
3/1/24 Glyco-engineered MDCK cells display preferred receptors of H3N2 influenza absent in eggs used for vaccines Reema Apte
3/8/24 Molecular mechanism of decision-making in glycosaminoglycan biosynthesis Jessica Perez
3/15/24 Cholera intoxication of human enteroids reveals interplay between decoy and functional glycoconjugate ligands Christy Armstrong
3/22/24 Glycan heterogeneity as a cause of the persistent fraction in HIV-1 neutralization Lydia Griggs
3/29/24 NO CLASS - CESAR CHAVEZ HOLIDAY