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Advances in Glycobiology

MED 225/CHEM 237/CMM 225
Offered every two years, Next Offering Spring 2023, First Day April 4, 2023
Location: Biomedical Research Facility 2 building, Room 1102
Time: 10:00am - 11:30am Tuesday & Thursday
Co-Directors: Jeffrey Esko and Philip Gordts

Additional Instructors

Prof. Hudson Freeze, Sanford Burnham Prebys
Prof. Carlos Hirschberg, Boston University
Prof. Markus Aebi, ETH Zurich
Prof. Gerald Hart, University of Georgia
Prof. James Paulson, Scripps Research
Prof. Richard Cummings, Harvard Medical School
Prof. Ron Schnaar, Johns Hopkins University

Units: 4
Grading is based on regular attendance and class participation.

*UCSD students and postdocs go to Canvas for assigned reading, study questions, and presentation materials.

Contact

Tracy Gilstrap
Education Program Specialist
(858) 882-1378
tgilstrap@health.ucsd.edu

*if you are off campus and would like access to the course materials please contact Tracy
Advanced elective for upper level undergraduates, graduate, and health sciences students who have taken Introduction to Glycoscience (Chem 142/242) and courses in cell biology or biochemistry. This course consists of  discussions of classic papers leading to modern concepts in glycobiology, with the objective of exploring the structure, metabolism, and function of glycans in biological systems. Students should develop a sense of the history of the field, seminal discoveries, and how these discoveries led to changes in the way scientists think about glycans. Students will be divided up into teams and make 1-2 presentations in consultation with a faculty member.

This year the course will be divided up into five modules:

DATE
​TOPIC/MODULE
​INSTRUCTOR 
PAPERS
4/4/23Introduction

LECTURE 1:
A Short History of Glycobiology
​Esko

Cummings

​4/6/23No Class Meeting due to San Diego Glycobiology Symposium
​4/11/23
MODULE 1:
Nucleotide Sugar Metabolism
​Carlos Hirschberg/ Jeff Esko

​4/13/23
MODULE 1:
Nucleotide Sugar Metabolism
​​Carlos Hirschberg/ Jeff Esko

​4/18/23
MODULE 1:
​Nucleotide Sugar Metabolism
​​Carlos Hirschberg/ Jeff Esko

​4/20/23
MODULE 1:
Nucleotide Sugar Metabolism
​​Carlos Hirschberg/ Jeff Esko

​4/25/23
MODULE 2:
N-glycans and Protein Folding
​Markus Aebi

​4/27/23
MODULE 2:
N-glycans and Protein Folding
​Markus Aebi

​5/2/23
MODULE 2:
N-glycans and Protein Folding
​Markus Aebi

​5/4/23
MODULE 2:
N-glycans and Protein Folding
​Markus Aebi

​5/9/23
​MODULE 3:
Discovery of O-GlcNAc
​Jerry Hart


​5/11/23
​MODULE 3:
Discovery of O-GlcNAc
​Jerry Hart

​5/16/23
​MODULE 3:
Discovery of O-GlcNAc
​Jerry Hart

​5/18/23
MODULE 3:
Discovery of O-GlcNAc
​Jerry Hart

​5/23/23
​MODULE 4:
Flu and glycan-protein interactions
​Jim Paulson


​5/25/23
MODULE 4:
Flu and glycan-protein interactions
​​Jim Paulson

​5/30/23
​MODULE 4:
Flu and glycan-protein interactions
​​ Jim Paulson

​6/1/23
​LECTURE 2:
History of lectins
​Ron Schnaar

​6/6/23
​MODULE 4 cont.:
Flu and glycan-protein interactions
​Jim Paulson

​6/8/23
​LECTURE 3:
Introduction to Bertozzi Nobel Prize / Watch Video
Bertozzi Nobel Prize
​Jeff Esko