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Edward Callaway

Edward Callaway, PhD

Adjunct Professor
Department of Neurosciences

Contact Information

Phone: 858.453.4100 x1158

Mailing Address:
Systems Neurobiology Laboratories
The Salk Institute for Biological Studies
10010 N. Torrey Pines Rd.
La Jolla, CA 92037

Lab Website

Organization and function of cortical circuits

Edward M. Callaway is a professor in the Systems Neurobiology Laboratories at The Salk Institute. His lab studies the organization and function of neural circuits in the visual cortex to better understand how specific neural components contribute to the computations that give rise to visual perception and to elucidate the basic neural mechanisms that underlie cortical function. They employ anatomical and physiological methods both in vivo and in vitro to reveal neuronal circuitry and to identify the emergent functional properties of the component neurons. Present studies focus on: the relationships between local circuits in primary visual cortex and early parallel visual pathways; connectivity and functional influence of distinct types of inhibitory cortical neurons. The lab is also actively developing and utilizing molecular and genetic methods to facilitate the elucidation and manipulation of neural circuits. These methods include: development of promoters that drive gene expression specifically in cell types of interest; genetic methods for selective and reversible neuronal inactivation; selective trans-synaptic viral labeling of neural circuits; viral delivery of genetic material to allow manipulation of circuits in species where typical transgenic technologies are impractical.

Nauhaus, I.*, Nielsen, K.J.*, Disney, A.A., Callaway, E.M. (In press) Orthogonal micro-organization of orientation and spatial frequency in primate primary visual cortex. Nature Neuroscience.

Li Y., Aimone, J.B., Xu, X., Callaway, E.M., Gage, F.H. (2012) Development of GABAergic inputs controls the contribution of maturing neurons to the adult hippocampal network. Proceedings of the National Academy of Sciences 109(11):4290-4295.

Marshel, J.H., Garrett, M.E., Nauhaus, I., Callaway, E.M. (2011) Functional specialization of seven mouse visual cortical areas. Neuron 72(6):1040-1054.

Nauhaus, I., Nielsen, K.J., Callaway, E.M. (2012) Nonlinearity of two-photon Ca2+ imaging yields distorted measurements of tuning for V1 neuronal populations. Journal of Neurophysiology 107(3):923-936.

Nielsen, K.J., Callaway, E.M., Krauzlis, R.J. (2012) Viral vector-based reversible neuronal inactivation and behavioral manipulation in the macaque monkey. Frontiers in Systems Neuroscience 6(48).

Vivar, C., Potter, M.C., Choi, J., Lee, J.Y., Stringer, T.P., Callaway, E.M., Gage, F.H., Suh, H., van Praag, H. (2012) Monosynaptic inputs to new neurons in the dentate gyrus. Nature Communications 3(1107).

Callaway, E.M., Borrel, V. (2011) Developmental sculpting of dendritic morphology of layer 4 neurons in visual cortex: influence of retinal input. Journal of Neuroscience 31(20): 7456-7470.

Choi, J., Callaway, E.M. (2011) Monosynaptic inputs to ErbB4 expressing neurons in mouse primary somatosensory cortex. Journal of Comparative Neurology 519(17):3402-3414.

Miyamichi, K., Amat, F., Moussavi F., Wang, C. Wickersham, I., Wall, N.R., Taniguchi, H., Tasic, B., Huang, Z.J., He, Z., Callaway, E.M., Horowitz, M.A., Luo, L. (2011) Cortical representations of olfactory input by trans-synaptic tracing. Nature 472(7342):191-196.

Osakada, F., Mori, T., Cetin, A.H., Marshel, J.H., Virgen, B., Callaway, E.M. (2011) New rabies variants for monitoring and manipulating activity and gene expression in defined neural circuits. Neuron 71(4): 617-631.