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Subhojit Roy

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The Roy lab's main interest is to explore mechanisms that convey and deposit cargoes into axons, dendrites and synapses. Towards this, they are broadly interested in physiologic neuronal transport/trafficking, and also potential abnormalities in these processes in neurodegenerative diseases like Alzheimer's and Parkinson's disease. Techniques used: Live imaging of neuronal trafficking using regular and photoactivatable fluorescent proteins, image-analysis, immunofluorescence, biochemistry, proteomics/bioinformatics (in collaboration with John Yates, Scripps) and data-driven computational modeling.

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Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid-beta protein oligomers. Tang Y, Scott D, Das U, Edland S, Radomski K, Koo E and Roy S*. Traffic, Feb 6 2012 online

A simple photoactivation and image-analysis module for visualizing and analyzing axonal transport with high temporal resolution. Roy S*, Yang Ge, Tang Y and Scott D. Nature Protocols, 2011 Dec 15;7(1):62-8

Mechanistic logic underlying the axonal transport of cytosolic proteins. Scott D, Das U, Tang Y and Roy S*. Neuron May 2011 12;70(3):441-54.

A pathologic cascade leading to synaptic dysfunction in รก-synuclein-induced neurodegeneration (2010). Scott D, Tabarean I, Tang Y, Cartier A, Masliah E, Roy S*. Journal of Neuroscience Jun 2010 16;30(24):8083-95.