In This Section:
Roger Tsien

Roger Tsien, PhD

Professor
Department of Pharmacology, Chemistry and Biochemistry

Contact Information

UC San Diego
9500 Gilman Drive #0647
La Jolla, CA 92093-0647

Office: (858) 534-4891
Lab: (858) 534-7009
Email: rtsien@ucsd.edu
Lab Website: http://www.tsienlab.ucsd.edu/

Roger Tsien's lab studies signal transduction, especially in neurons and cancer cells, with the help of designed molecules, imaging, and photochemical manipulation.

John Y. Lin, Sharon B.Sann, Keming Zhou, Sadegh Nabavi, Christophe D. Proulx, Roberto Malinow, Yishi Jin and Roger Y. Tsien. Optogenetic Inhibition of Synaptic Release with Chromophore-Assisted Light Inactivation (CALI). Neuron 79: 241–253

Michael Whitney, Elamprakash N. Savariar, Beth Friedman, Rachel A. Levin, Jessica L. Crisp, Heather L. Glasgow, Roy Lefkowitz, Stephen R. Adams, PaulSteinbach, Nadia Nashi, Quyen T. Nguyen, and Roger Y. Tsien 2013. Ratiometric Activatable Cell-Penetrating Peptides Provide Rapid In Vivo Readout of Thrombin Activation. Angew. Chem. Int. 52 325–330

Michael Whitney, Elamprakash N. Savariar, Beth Friedman, Rachel A. Levin, Jessica L. Crisp, Heather L. Glasgow, Roy Lefkowitz, Stephen R. Adams, PaulSteinbach, Nadia Nashi, Quyen T. Nguyen, and Roger Y. Tsien 2013. Ratiometric Activatable Cell-Penetrating Peptides Provide Rapid In Vivo Readout of Thrombin Activation. Angew. Chem. Int. 52 325–330

Margaret T. Butkoa, Jeffrey N. Savasb, Beth Friedmana, Claire Delahunty, Ford Ebnerc, John R. Yates III, and Roger Y. Tsien 2013. In vivo quantitative proteomics of somatosensory cortical synapses shows which protein levels are modulated by sensory deprivation. PNAS

Eilon Shania, Roy Weinstain, Yi Zhanga, Cristina Castillejo, Eirini Kaiserli, Joanne Chory, Roger Y. Tsienbf, and Mark Estellea 2013. Gibberellins accumulate in the elongating endodermal cells of Arabidopsis root. PNAS

Elamprakash N. Savariar, Csilla N. Felsen, Nadia Nashi, Tao Jiang, Lesley G. Ellies, Paul Steinbach, Roger Y. Tsien, and Quyen T. Nguyen 2013. Real-time In Vivo Molecular Detection of Primary Tumors and Metastases with Ratiometric Activatable Cell-Penetrating Peptides. Cancer Res 73:2 855-864

Margaret T Butko, Jin Yang, Yang Geng, Hyung Joon Kim, Noo Li Jeon, Xiaokun Shu1, Mason R Mackey, Mark H Ellisman, Roger Y Tsien & Michael Z Lin 2012. Fluorescent and photo-oxidizing TimeSTAMP tags track protein fates in light and electron microscopy. Nature Neuroscience. 15:12 1742-1751

Horng D. Ou, Witek Kwiatkowski, Thomas J. Deerinck, Andrew Noske, Katie Y. Blain, Hannah S. Land, Conrado Soria, Colin J. Powers, Andrew P. May, Xiaokun Shu, Roger Y. Tsien, James A.J. Fitzpatrick, Jeff A. Long, Mark H. Ellisman, Senyon Choe, and Clodagh C. O’Shea 2012. A Structural Basis for the Assembly and Functions of a Viral Polymer that Inactivates Multiple Tumor Suppressors. Cell 151: 304–319

Amy J Lam, François St-Pierre, Yiyang Gong, Jesse D Marshall, Paula J Cranfill, Michelle A Baird, Michael R McKeown, Jörg Wiedenmann, Michael W Davidson, Mark J Schnitzer, Roger Y Tsien, & Michael Z Lin 2012. Improving FRET dynamic range with bright green and red fluorescent proteins. Nature Methods 9:10 1005-1012

Yingchuan B. Qi, Emma J. Garren, Xiaokun Shu, Roger Y. Tsien, and Yishi Jin 2012. Photo-inducible cell ablation in Caenorhabditis elegans using the genetically encoded singlet oxygen generating protein miniSOG. PNAS 109 :19 7499–7504

Emilia S. Olson, Michael A. Whitney, Beth Friedman, Todd A. Aguilera, Jessica L. Crisp, Fred M. Baik, Tao Jiang, Stephen M. Baird, Sotirios Tsimikas, Roger Y. Tsien and Quyen T. Nguyen 2012. In vivo fluorescence imaging of atherosclerotic plaques with activatable cell-penetrating peptides targeting thrombin activity. Integr. Biol., 4: 595–605

Xiaokun Shu1, Varda Lev-Ram, Thomas J. Deerinck, Yingchuan Qi1, Ericka B. Ramko, Michael W. Davidson, Yishi Jin1, Mark H. Ellisman, Roger Y. Tsien 2012. A Genetically Encoded Tag for Correlated Light and Electron Microscopy of Intact Cells, Tissues, and Organisms. PLoS Biology, 9:4

Yingchuan B. Qia, Emma J. Garrena, Xiaokun Shub, Roger Y. Tsien, and Yishi Jina 2012. Photo-inducible cell ablation in Caenorhabditis elegans using the genetically encoded singlet oxygen generating protein miniSOG. PNAS 109: 7499–7504

Evan W. Miller, John Y. Lina, E. Paxon Frady, Paul A. Steinbach, William B. Kristan, Jr., and Roger Y. Tsien 2012. Optically monitoring voltage in neurons by photoinduced electron transfer through molecular wires. PNAS 109: 2114–2119

Bo Chen, Beth Friedman, Michael A. Whitney, Jessica A. Van Winkle, I-Farn Lei, Emilia S. Olson, Qun Cheng, Benedict Pereira,Lifu Zhao, Roger Y. Tsien, and Patrick D. Lyden 2012. Thrombin Activity Associated with Neuronal Damage during Acute Focal Ischemia, J. Neuro Science, 32:7622–7631