Jeffrey Goldberg, MD, PhD

Jeffrey Goldberg, MD, PhD

Professor and Director of Research

Contact Information

Shiley Eye Institute, UC San Diego
9415 Campus Point Drive
La Jolla, CA 92093
Office: 858-534-9794

The Goldberg lab studies survival and regeneration in the visual system. With a focus on molecular and developmental regulation of signaling and transcription, they use a combination of techniques ranging from in vitro assays to various in vivo models, with a goal of reversing the regenerative failure seen after injury or in neurodegenerative diseases like glaucoma or ischemic optic neuropathy. The lab maintains interests in stem cell biology relevant to retinal development and cell therapy, and in the use bioengineering approaches including magnetic nanoparticles and 3D scaffolds for tissue engineering.

J. Hertz, B. Qu, Y. Hu, R. Patel, D. Valenzuela, J.L. Goldberg (2013). Survival and Integration of Developing and Progenitor-Derived Retinal Ganglion Cells Following Transplantation. Cell Transplantation, in press.

K.E. Kador, R.B. Montero, P. Venugopalan, J. Hertz, A.N. Zindell, D.A. Valenzuela, M.S. Uddin, E.B. Lavik, K.J. Muller, F.M. Andreopoulos, J.L. Goldberg (2013). Tissue Engineering the Retinal Ganglion Cell Nerve Fiber Layer. Biomaterials, in press.

Y. Wang, D.P. Brown, Y. Duan, W. Kong, B.D. Watson, and J.L. Goldberg (2012). A novel rodent model of posterior ischemic optic neuropathy. Archives of Ophthalmology, in press.

R.G. Corredor, W. Pita-Thomas, E.F. Trakhtenberg, Y. Hu, and J.L. Goldberg (2012). Soluble adenylyl cyclase activity is necessary for retinal ganglion cell survival and axon growth. J Neuroscience 32(22):7734-44. PMC PENDING

M.G. Blackmore, Z. Wang, J. Lerch, Dario Motti, Yi-Ping Zhang, C. Shields, J.K. Lee, J.L. Goldberg, V.P. Lemmon, and J.L. Bixby (2012). KLF7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract. PNAS 109(19):7517-22. PMC PENDING

J.L. Goldberg (2012). Role of Electrical Activity in Neural Repair. Neuroscience Letters, epub ahead of print. PMC3360133

E.E. Chang, J.L. Goldberg (2012). Glaucoma 2.0: Neuroprotection, Neuroregeneration, Neuroenhancement. Ophthalmology, 119(5):979-86. PMC3343191

M.B. Steketee, S.N. Moysidis, X.-L. Jin, J.E. Weinstein, W. Pita-Thomas, H.B. Raju, S. Iqbal and J.L. Goldberg (2011). Nanoparticle-Mediated Signaling Endosome Localization Regulates Growth Cone Motility and Neurite Growth. PNAS, 108(47):19042-7. PMC PENDING

E.F. Trakhtenberg, J.L. Goldberg (2011). Neuroimmune Communication. Science 334(6052):47-8. PMC PENDING

D. L. Moore, M. G. Blackmore, Y. Hu, K. H. Kaestner, J. L. Bixby, V. P. Lemmon, and J. L. Goldberg (2009). KLF Family Members Regulate Intrinsic Axon Regeneration Ability. Science, 326:298-301. PMC2882032