Our laboratory is interested in the signal transduction molecules that mediate cellular interactions during development of the mammalian nervous and immune systems. We employ several experimental models, most of them in the mouse, which exploit both cell culture and molecular genetics.
Over the last several years, we have focused in particular on three receptor protein-tyrosine kinase signaling systems: the ErbB receptors and their ligands of the neuregulin family, the Eph receptors and their ephrin ligands, and the Tyro3/TAM family receptors and their ligands Gas6 and Protein S. We have investigated the roles that these proteins play in neural development by engineering and then analyzing knock-out and knock-in mutations in their corresponding genes in the chick and mouse.
Lu, Q., Gore, M., Zhang, Q., Camenisch, T., Boast, S., Casagrande, F., Lai, C. Skinner, M., Klein, R., Matsushima, G.K., Earp, H.S., Goff, S. P. and Lemke, G. (1999) Receptor tyrosine kinases of the T
Bertuzzi, S., Hindges, R., Mui, S.H., O'Leary, D.D. and Lemke, G.(1999) The homeodomain protein vax1 is required for axon guidance and major tract formation in the developing forebrain. Genes Dev. 13
Brown, A., Yates, P.A., Burrola, P., Ortuno, D., Vaidya, A., Jessell, T.M., Pfaff, S.L., O'Leary, D.D. and Lemke G. (2000) Topographic mapping from the retina to the midbrain is controlled by relative
Lu, Q. and Lemke, G. (2001) Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family. Science 293: 306-311.
Mui, S.H., Hindges, R., O'Leary, D.D.M., Lemke, G., and Bertuzzi, S. (2002) The homeodomain protein Vax2 patterns the dorsoventral and nasotemporal axes of the eye. Development 129: 797-804.