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Gery Schulteis, PhD

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Understanding mechanisms of neural plasticity is the guiding theme of our laboratory's research endeavor, with a current emphasis on neuroadaptation to drugs of abuse. We employ a variety of behavioral, physiological, and neuropharmacological techniques in awake, behaving rodents to study the physiology and pharmacology of drugs of abuse, including opioids (morphine, heroin), benzodiazepines (Valium, Librium), and alcohol. Acute or chronic treatment with these drugs leads to neuroadaptive changes that express themselves functionally as drug tolerance, dependence, and withdrawal, and we are interested in elucidating the neural mechanisms which mediate these phenomena. Tools and techniques employed to achieve our research goals include brain stimulation reward, intravenous (opioid) and oral (ethanol) self-administration of drugs, radiotelemetric monitoring of autonomic function, whole body plethysmography to study respiratory function, and a variety of pain sensitivity assays.

Schulteis, G., Ahmed, S., Morse, A. C. Koob, G. F., & Everitt, B. J., (2000). Lesions of the basolateral nucleus of the amygdala abolish conditioned opiate withdrawal. Nature, 405, 1013-1014.

Azar, M. R., Jones, B. C., & Schulteis, G. (2003). Conditioned place aversion is a highly sensitive index of acute opioid dependence and withdrawal. Psychopharmacology, 170, 42-50.

Liu, J., & Schulteis, G. (2004). Brain reward deficits accompany naloxone-precipitated withdrawal from acute opioid dependence. Pharmacology Biochemistry and Behavior, 79, 101-108.

Amitai, N., Liu, J., & Schulteis, G. (2006). Discrete cues paired with naloxone-precipitated withdrawal from acute morphine dependence elicit conditioned withdrawal responses. Behavioural Pharmacology, 17, 213-222.

Schulteis, G., & Liu, J. (2006). Brain reward deficits accompany withdrawal (hangover) from acute ethanol in rats. Alcohol, 39, 21-28.

View a full list of Gery Shulteis PubMed publications.