The work in my laboratory centers on mechanisms responsible for synaptic transmission. These problems are approached by a combination of molecular biological, electrophysiological, anatomical, and theoretical methods. We study neurons both in dissociated cell culture and in brain slices, and we also investigate the function of individual membrane proteins of importance for synaptic transmission. One main current research focus is the various mechanisms used by the central nervous system for the short-and long-term regulation of synaptic strength. A second principal project uses a combination of methods to elucidate the molecular basis to neurotransmitter release at synapses.
Dobrunz, L. and Stevens, C.F. (1999). Response of Hippocampal Synapses to Natural Stimulation Patterns. Neuron 22: 157-166.
Murthy, V.N. and Stevens, C.F. (1999) Reversal of Synaptic Vesicle Docking at Central Synapses. Nature Neuroscience 2: 503-507.
Wesseling, J. and Stevens, C.F. (1999) Identification of a Novel Process Limiting the Rate of Synaptic Vesicle Cycling at Hippocampal Synapses. Neuron 24: 1017-1028.
McAllister, A.K. and Stevens, C.F. (2000) Nonsaturation of AMPA and NMDA receptors at hippocampal synapses. PNAS 97: 6173-6178.