Anna Devor, PhD

Our research program is focused on real time detection of brain activity across scales: from cellular and molecular activity of neuronal circuits in animals to noninvasive brain imaging in humans. To this end, we assemble a suite of micro- and nanoscopic technologies that, collectively, allow precise and quantitative probing of large numbers of the relevant physiological parameters. Then, we combine multimodal measurements and system-level analysis/modeling, commonly used in engineering disciplines, to understand how specific patterns of microscopic brain activity (and their pathological departures) translate into noninvasive macroscopic observables obtained with functional Magnetic Resonance Imaging (fMRI) and magnetoencephalography (MEG). The overarching goal is to develop a single estimation framework for inference of neuronal network activity from multimodal human fMRI/MEG imaging data.

In vivo alterations in calcium buffering capacity in transgenic mouse model of synucleinopathy. Lidia Reznichenko, Qun Cheng, Krystal Nizar, Sergey L. Gratiy, Payam A. Saisan, Edward M. Rockenstein, Tanya Gonzalez, Christina Patrick, Brian Spencer, Paula Desplats, Anders M. Dale, Anna Devor, Eliezer Masliah. J Neurosci. 2012 Jul 18;32(29):9992-8.

Neuronal basis of non-invasive functional imaging: from BOLD fMRI to the underlying microscopic neurovascular dynamics. Devor A, Boas DA, Einevoll GT, Buxton RB, Dale AM. In Neural Metabolism In Vivo: 4 (Advances in Neurobiology). Chapter 15. Volume Editor, In-Young Choi. 2012, Springer.

Neurovascular imaging. Devor A,Boas DA. Front Neuroenergetics. 2012;4:1. Epub 2012 Jan 18.

On the estimation of population-specific synaptic currents from laminar multielectrode recordings. Gratiy SL, Devor A, Einevoll GT, Dale AM. Front Neuroinform. 2011;5:32. Epub 2011 Dec 20.

Frontiers in optical imaging of cerebral blood flow and metabolism. Devor A, Sakadzic S, Srinivasan VJ, Yaseen MA, Nizar K, Saisan PA, Tian P, Dale AM, Vinogradov SA, Franceschini MA, Boas DA. J Cereb Blood Flow Metab. 2012 Jan 18. doi: 10.1038/jcbfm.2011.195.

"Overshoot" of O2 is required to maintain baseline tissue oxygenation at locations distal to blood vessels. Devor A, Sakadzic S., Saisan PA, Yaseen MA, Roussakis E, Srinivasan VJ, Vinogradov SA, Rosen BR, Buxton RB, Dale AM, Boas DA. J Neurosci. 2011 Sep 21;31(38):13676-81.

Two-photon microscopy of cortical NADH fluorescence intensity changes: Correcting contamination from the hemodynamic response. Baraghis E, Devor A, Fang Q, Srinivasan VJ, Wu W, Lesage F, Ayata C, Kasischke KA, Boas DA, Sakadzic S. J Biomed Opt. 2011 Oct;16(10):106003.

Monte Carlo simulation of the spatial resolution and depth sensitivity of two dimensional optical imaging of the brain. Tian P, Devor A, Sakadžic S, Dale AM, Boas DA. J Biomed. Opt. 2011 Jan/Feb;16(1):016006.